Apart from Native 4Kn (4K physical sector drives) all HDD's new, old, slow, fast, small and big should work just fine provided they are formatted correctly.
http://www.futeko.com/newforum/index.php?topic=576.0
That Samsung indeed looks to be defect as disappearing is absolutely not normal unless a faulty cable is used.
Currently using a 10-slot HDD Icy Box Docking Station which also works fine with a whopping 10x HDD connected on a single USB3 port.