I am using a FANTEC QB-35US3.
The HDDs in it: 1x6TB WD Green and 3x4TB WD Green
On USB2 Ports always without problems (as I wrote on Q5 4K and Q10 Pro), but if I plug it to the USB3 Port, it lasts some days and suddenly one or more of the HDDs are missing after a startup.

If I then put the Fantec back to one of the USB2 ports, all HDDs are back again.

Because of that problem, I try not to use the USB3 ports of the Mediaplayers any more.