No problem but if you need to use the wrapper you can't use UPNP.
SMB and NFS only.
There's no need actually for UPNP. Himedia is fully able to read the containers with video or audio over NFS or SMB and do the decoding by itself. It needs no features offered by UPNP so why one would use that?
To answer to OP - I can confirm what all other people are saying - no problems whatsoever! Unless you're planning to use a second SMB-based storage and hit the limit with user/pass; Himedia remembers only one combination and it's weird to try to convince it to remember 2 combinations. In that case better use NFS.